Manager of Downstream Processing

Manager of Downstream Processing
Core Biogenesis, France

Experience
1 Year
Salary
0 - 0
Job Type
Job Shift
Job Category
Traveling
No
Career Level
Telecommute
No
Qualification
Bachelor's Degree
Total Vacancies
1 Job
Posted on
Jul 23, 2021
Last Date
Aug 23, 2021
Location(s)

Job Description

Core Biogenesis leverages the scalability of plants to simplify and accelerate the mass-production of sustainable, high-performance recombinant molecules used today in Cultured Meat and Cellular Therapy and a new generation of biopharmaceuticals.

By using plants and proprietary synthetic biology technologies to build the world’s most scalable bioproduction platform, we aim to unlock the promises of the bioeconomy.

Core Biogenesis is a young and rapidly scaling biotechnology startup, based in Paris, France. Founded in 2020 by Chouaïb Meziadi and Alexandre Reeber, it is backed by some of the best European investors including Entrepreneur First and XAnge.

Reporting to the Chief Scientific Officer, the Manager of Downstream Processing will develop processes that will maximize stewardship, safety, quality and productivity. You will be responsible for building a downstream purification suite from scratch, not only designing the space but also identifying the most relevant equipment to use. You should display advanced technical knowledge and scientific understanding of protein purification and have a strong background in manufacturing recombinant proteins for a diverse product portfolio.

Responsibilities
  • Implement downstream protein purification processes and transition to cGMP and ISO 9000 as appropriate
  • Manage the design, planning, operation as well as the monitoring of all DSP activities and cGMP production from lab to manufacturing scale.
  • Oversee development of purification protocols using chromatography (AKTA platform), filtration, clarification, column packing, and flow filtration
  • Coordinate and collaborate with the Upstream Manager to determine appropriate methods for protein purification.
  • Responsible for representing the DSP team during audits and inspections by regulatory authorities.
  • Conduct appropriate data analysis, and curate records and reports for downstream purification batches, which you will revise accordingly
  • Ensure the timely and cost-efficient delivery of batches of purified recombinant proteins
  • Ensure alignment with regulatory and quality requirements
  • Introduce innovative technologies within the DSP department and follow the latest trends for innovative biotechnology products

Requirements

Must Have:

  • Relevant academic degree in Pharmacology, Biochemistry, Biochemical engineering or related discipline
  • +5 years of hands-on experience in Pharmaceutics, Biotechnology or related fields, preferably in a commercial environment
  • Experience in planning and assembling downstream processing facilities
  • Extensive knowledge of protein biochemistry and protein purification steps
  • Previous exposure to scaling experiences from lab scale to large scale manufacturing
  • Proven experience in process development and operating a cGMP environment
  • Experience in chromatography and filtration
  • Knowledge of standard operating procedures (SOP) and batch records
  • Understanding of analytical methods including assay development and electrophoresis
  • Highly self-motivated individual capable of working with aggressive timelines
  • Great interpersonal and communication skills, proficiency in English

Nice to Have:

  • Exposure to Lean Six Sigma values and ISO 9000 manufacturing
  • Understanding of plant-based production systems

Benefits

  • Private Health Insurance
  • Competitive salary and equity package.
  • Paid Time Off
  • Training amp; Development

Job Specification

Job Rewards and Benefits

Core Biogenesis

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